The airport's leaseholder Stobart Air reached an agreement with Carlisle City Council earlier this year paving the way for work to start on a freight storage and distribution facility.
But local resident Gordon Brown, from Irthington, objected to the plans and sought an injunction to overturn the local planning authority's approval. However, ruling in the High Court, Mr Justice Owen declared that most of Brown's case was "unarguable" and found in favour of the council.
Stobart Air had scaled down its original proposal, which it submitted in 2007. The redrafted proposal excluded a realignment of the runway after the original application was called in by the Government Office for the North West.
The second application did not depart from the provisions of the local plan and was agreed by the council in March this year.