Property development and investment company Cole Waterhouse has submitted a full planning application to Birmingham City Council for the site at Upper Trinity Street in Digbeth.
The site is currently a mix of former industrial buildings and a carpark.
According to a statement issued by the developer, the proposed development, known as Upper Trinity Street, comprises almost 550 square metres of "creative, retail, leisure and workspace, and over 900 new homes with a mix of private sale and build to rent apartments".
Also included in the proposal is a 133-bedroom hotel. The planning application has yet to be published on the council's website.
Planning consultancy Barton Wilmore is acting on behalf of Cole Waterhouse.
Antony Harding, planning associate at Barton Wilmore, said: "This is an important scheme in Digbeth's continuing evolution. It's a site which has largely been forgotten about and unloved for decades.
"The residential element within Digbeth is much needed and goes some way to start positively creating communities again and addressing the impact made by the mass building clearance within Digbeth in the 1960s."
Last month, plans were submitted for 722 build-to-rent homes in a new 39-storey tower on a car park site in Birmingham city centre.