Developer Hammerson has submitted a planning application to Birmingham City Council for the regeneration of its Martineau Galleries site.
The site includes the Square Shopping Centre, Dale End car park and 1-7 Dale End.
Proposals include the delivery of 1,300 new homes for rent and purchase, and up to 130,000 square metres of workspace, as well as a new city centre hotel, restaurants and cafes.
According to the developer, a tall building rising up to 35 storeys will form a focal point to the scheme. Other buildings range from 10-20 storeys and commercial plots range from 10-15 storeys, the developer said.
Martineau Galleries is identified in the 2017 Birmingham Development Plan as a major development site in the city centre.
Last week, the former housing secretary approved plans for an 800-home development on an unallocated former golf club site to the south east of Birmingham. This was in line with a recommendation from an inspector who rejected the council's argument that the scheme was too big to be considered as a windfall site and claimed that provision of affordable housing in the city had "collapsed".