Developer Peel Land and Property has submitted an outline application for the proposal to Salford City Council.
The development is earmarked for a site between the Broadway Metrolink stop and Michigan Avenue in Salford Quays, to the east of the MediaCityUK development.
Along with the 1,500 apartments - which would be a mix of co-living and student accommodation - the development proposes up to 2,250 square meters of commercial floorspace.
The layout of the scheme has yet to be finalised, but a document submitted with the application say the development would be delivered in three to six apartment blocks, with a maximum height of about 45 storeys.
According to the document, the site is currently allocated for employment use, but the allocation of the site for residential use "will not prejudice existing employment operations and will make an important contribution towards the city’s regeneration objectives without impacting upon its employment land supply".
It says the proposed development "represents high density residential development in Greater Manchester’s Regional Centre". It adds that this is supported by the local planning policies "which promote high density development in the regional centre to efficiently use the city’s brownfield land to maximise its regeneration benefits".
Last week, a London borough refused plans for a 499-home high-density mixed-use redevelopment of a business park.
Yesterday, the housing secretary refused permission for a 220-home, 17-storey tower in south London on design grounds, against the advice of a planning inspector.
Earlier this week, it was announced that a revised draft of Greater Manchester's emerging spatial plan will be published for consultation in January.