The 10.5-hectare site at Ebrington is the largest single regeneration site in the city.
Planners said in their development management report that the mixed-use development, will is intended to include museums, commercial office space, venues for creative industries and education, as well as cafes, restaurants and parking, "has the potential to deliver significant direct and indirect socio-economic benefits to the Waterside area and wider city".
It concludes that the "proposal accords broadly with prevailing planning policy and the local development plan" and recommends for approval to be granted.
Last week, the Department of the Environment, which deals with major planning applications in Northern Ireland, announced that the environment minister had approved the scheme.
Applicant Ilex, an urban regeneration company, said the development is likely to create 2,400 jobs.
Durkan said that "this application sets out a blueprint that will be a boost for business, tourism and people in the area by revitalising the 1840s site with new homes, offices, cafes, restaurants and museum and arts facilities. It will also bring many construction jobs in the short term as well as long-term job creation.
"Approval of this development framework provides certainty on the scale and type of development that will be acceptable. It will provide a masterplan for the physical regeneration and investment priorities for this pivotal site which is connected to the city centre by the iconic Peace Bridge."