The revised plans passed this week by the London Borough of Haringey update previous proposals which were approved in 2011.
The latest proposals include an increase of 4,750 seats at the stadium to a capacity of 61,000, as well as a retractable pitch allowing the stadium to host a range of sporting and non-sporting events.
Three hundred extra homes have also been permitted, giving a total of 585 in four towers up to 35 storeys high. A 180-bed hotel is also included in the scheme, as is 4,000 square metres of community and office space.
A planning report said that a council conservation officer concluded that the demolition of three listed buildings – the Edmonton Dispensary, the former White Hart pub and the Red House - to make way for the scheme would "result in substantial harm to the Tottenham High Road Conservation Area".
The conservation officer added that the overall scheme would have a negative impact on views from the conservation area.
"Overall the scheme is considered to result in substantial harm to the conservation area," the report said.
However, the report said the harm was "necessary" to achieve the public benefits of the proposals. It added that the area’s development plan promoted sports-led regeneration on the site. Planners recommended that the application be approved.
Haringey Council leader Claire Kober said: "We’re delighted to see these exciting plans approved, which will support our long-term regeneration plans and write a new chapter in Spurs’ long and successful history in our borough.
"These proposals are about more than just a new stadium – they bring much-needed new jobs and a boost to the economy, with thousands more fans spending money in local businesses."