The register includes listed buildings, places of worship, industrial sites, scheduled monuments and other sites that have been identified as being in need of rescue.
English Heritage has identified five sites in particular which are in need of regeneration, including the Police and Fire Station on London Road, Manchester, the Price and Kensington Teapot Works in Stoke on Trent and the Pump House at Abbey Mills, London, all of which have no plans for future use.
Previous proposals for one of the sites, the Carriage Works in Bristol, failed to gain planning permission, but a housing association recently put forward proposals for the site and another scheme is being prepared by a private developer, English Heritage said.
Planning permission has been granted for the mixed-use redevelopment of the fifth building, the State Cinema in Thurrock, Essex, but no progress has been made so far, according to the watchdog.
English Heritage chief executive Simon Thurley said: "Although there has been a reduction in the number of sites on the register, more than a third of buildings that were on the national register when it first began in 1999 are still there now.
"We can't give up on all these incredibly important historic buildings; getting them back in use will lift the blight from historic areas, bringing back in to use really important buildings and giving people a sense of pride in where they live."
Eastbourne Pier, which was damaged by fire this summer, has been added to the register, along with the largest and most complete tin mine in Europe, Geevor in the West of Cornwall.
Other sites added include the 18th century shipwreck Hazardous in Bracklesham Bay, Sussex, and Bedlam Furnaces at Ironbridge Gorge in Shropshire.
English Heritage said that sites that have been rescued in the past year and taken off the list include Langham Airfield Dome in Norfolk, Newman Brothers Coffin Works in Birmingham, the London tomb of the performer Emile Blondin and the wreck of early 20th century submarine the Holland No. 5 off the South East Coast.
More details on the list can be found here.