Isle of Anglesey County Council approved developer Land and Lakes’ proposals for Penrhos Leisure Village in November, after earlier rejecting the plans against officers’ advice.
The outline proposals include a 500-unit leisure park including cottages, lodges, a waterpark and beach, cafés, restaurants and a farmers market at the Penrhos Coastal Park in Holyhead, which is an Area of Outstanding Natural Beauty.
Permission was also given for an additional 315 lodges, a 75-bed hotel, a new coastal nature reserve and outdoor sports facilities at At Cae Glas, and up to 320 new homes at Kingsland.
Under the proposals, the hotel, lodges, and Kingsland homes would initially be used as worker accommodation for the construction of the proposed Wylfa B nuclear power station.
A decision letter signed off on behalf of minister for housing and regeneration Carl Sargeant and dated 7 March confirmed the application would not be subjected to further ministerial scrutiny.
Land and Lakes chief executive Richard Sidi said the decision paved the way for the finalisation of a Section 106 Agreement.
"We will also be continuing negotiations with Horizon regarding the delivery of accommodation for their nuclear workers," he said.
"This is an important time for Anglesey to manage the impact of some major energy-related projects and it is extremely important that we all work together to coordinate these developments to maximise the economic benefits for the island whilst minimising any detrimental effects on this beautiful part of the country."
Jon Suckley, partner at project consultants HOW Planning, said the development would "completely transform" the area.
"It will not only provide an exciting new focus for high quality and sensitive development but it will also create hundreds of new jobs and attract much needed new investment to the area," he said.