Manchester Airports Group (MAG), which owns the airport, has lodged the outline planning application with Manchester City Council.
The scheme involves the phased redevelopment of the site to the north of the airport’s terminals and railway station, with 113,433 square metres of new offices, 49,046 square metres of advanced manufacturing, and 5,761 square metres of retail, leisure and community facilities.
Also proposed are 1,293 hotel beds, 4,182 car parking spaces, a 5-hectare central park, and a new bridge over the M56 spur road.
MAG said the development, sited on the edge of the Wythenshawe area of the city, aims to create 11,400 jobs.
The proposals form part of the 60.7-hectare Airport City scheme, unveiled by chancellor George Osborne in January, which aims to transform the area into a global business hub.
The latest application is in the North Airport City area. Last month, MAG received outline permission for the World Logistics Hub development, including 130,000 square metres of logistics space, in the southern part of Airport City, next to junction 6 of the M56 motorway.
MAG’s Airport City director, John Atkins, said: "We have been working on this project for six years, examining airport cities across the world and how Manchester can successfully apply the concept.
"The planning submission demonstrates the progress we have made in the past 12 months and is a major step forward towards starting work on site.
"Airport City will attract investment from international businesses and become a catalyst for the wider long term regeneration of Wythenshawe, with the creation of thousands of new jobs."