It was created by Tayplan, a body covering the Dundee City, Angus and Perth & Kinross council areas, together with the northern part of Fife.
Tayplan convenor John Beare said: "I am delighted that the hard work and efforts of a great number of people has brought the plan to the stage of submission to ministers."
If approved, the plan will replace the existing structure plans of the councils concerned.
The plan is based around a vision that by 2032 the region will be sustainable, more attractive, competitive and vibrant without creating an unacceptable burden on the planet.
It seeks to promote a standard of quality of life that "will make it a place of first choice where more people choose to live, work and visit, and where businesses choose to invest and create jobs", a Tayplan statement said.