A report by a council planning officer recommends refusal due to the growing concentration of bars in the area.
The officer said: "The growth of the night time economy in this area is an important component of its overall success.
"But, in a similar way...the growth of this sector can and has caused issues elsewhere in the city centre, and there are indications from that the growth of the sector in the Northern Quarter is beginning to cause problems relating to crime and disorder which could undermine the regeneration of the area."
Responding to the application, the council’s city centre regeneration team voiced concerns that most of the investment in the Thomas Street part of the Northern Quarter in the past two years has been in restaurants and bars.
The response said: "This has resulted in a situation where this type of use dominates this part of the Northern Quarter in a way that has affected its feel and character.
The Northern Quarter sits between the main Manchester retail and commercial area, Piccadilly Gateway, Ancoats and Shudehill.
In 1995, the council produced a regeneration strategy aimed at improving the area by building on its creative base and developing it as a mixed use area.