It will include a north main tower at Clyde Wharf, a north intermediate tower to support the cable, and a south main tower to the south of the Queen Elizabeth II pier near the O2 Dome.
There will also be a two-storey station on either side of the river, incorporating the mechanical drive rooms, concourses and ticket offices. The gondola arrival and departure points will be on the first floor, with retail space on the ground floor.
Three planning applications are being submitted simultaneously to the London Borough of Greenwich, the London Borough of Newham and the London Thames Gateway Corporation.
The plans for the scheme, which has an estimated construction cost of £25 million, were unveiled in July and the aim is to fund it entirely from private finance.
It is hoped the application will be determined by January 2011.